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Going Beyond RECIST – Part 3 Making Volumetric Tumor Measurements:  The Nuts and Bolts  [Part 3 of our 3 Part series on Going Beyond RECIST: a look at volumetric and functional tumor analysis in oncology clinical trials.]  Volume-based measurements and functional imaging, which encompass the whole tumor and reflect physiological changes, can be used to make both morphological and functional measurements, and in certain instances, may allow clinicians to more accurately assess response.  Segmentation Read more

Going Beyond RECIST – Part 2 Why It’s Important to Add Volume Data to a Clinical Study [Part 2 of our 3 Part series on Going Beyond RECIST: a look at volumetric and functional tumor analysis in oncology clinical trials.] Capturing tumor volume data during a clinical trial can add significant value to a study. Three-dimensional measurements can be easily incorporated into existing clinical trial workflows using cloud-based automated image acquisition and management software Read more

Going Beyond RECIST – Part 1 Are Volumetric Assessments a True Reflection of Drug Response? [Part 1 of our 3 Part series on Going Beyond RECIST: a look at volumetric and functional tumor analysis in oncology clinical trials.] Medical imaging is an integral part of oncology clinical trial design due to its non-invasive nature and its ability to detect biological and physiological phenomena. Traditionally, anatomical quantitative image analysis relied on linear measurements of tumor Read more

Immunotherapies display novel response patterns that affect the design of imaging based studies and the subsequent evaluation of imaging data. Applying traditional chemotherapy-based response assumptions to immunotherapy trials can result in inaccurate interpretation of response, premature therapy termination, and unnecessary removal of subjects from a trial. Therefore, a thorough understanding of these response patterns and the new criteria used to assess them is critical for conducting a successful clinical trial for immunotherapy. Today, a Read more

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